Furthermore, MicroED data exploits already existing analysis programs that were originally written for X-ray diffraction. The use of nano-sized crystals overcomes a significant bottleneck in X-ray crystallography, which requires micron-sized crystals or larger. In this method, the crystal is continuously tilted in the cryo-electron microscope (cryo-EM) while diffraction information is recorded. The MicroED system is currently installed on CEMAS’ Thermo Scientific Glacios Cryo-TEM. Ohio State’s Center for Electron Microscopy and Analysis (CEMAS) is positioned to amplify characterization capabilities and advance research involving MicroED. These nanocrystals are too small for traditional X-ray crystallography. Micro-Electron Diffraction (MicroEd) has created excitement in the scientific community as a new electron microscopy method to determine the structure of nano-sized crystals. Figure B) Top: carbamazepine modeled into density bottom: carbamazepine molecule as a skeletal formula. Figure A) Diffraction pattern of a carbamazepine crystal.
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